Having a Collection - Many people collect things. Your work at home business could target product niches such as trading cards, coins, nick-knacks, dolls, plates, old books, glassware, comic books, stamps, or anything else you can think of that people tend to collect.
Attracting Men/Women - Most people want to be attractive to the opposite sex, or even the same sex in many cases. You could target product niches like flirting tips, makeovers, attractive clothing styles, perfumes, colognes, etc...
Saving Memories - Pretty much everyone likes to retain memories of special occasions, parties, vacations, and anything else worth looking back on. They want to maintain them and have them to show to their families and friends. Your website could target work at home niches like cameras, camcorders, photo albums, diaries, journals, etc...