You can spend a load of time on a campaign and get it profiting great, only to have it die the next day. The advertiser can pull the offer, your payout can get cut, you can be completely cut from the offer, etc. Don’t flip out, realize that this is a part of the industry and move on. Search for a similar offer to promote. If you can’t find anything, quit struggling and just call it a day and start on something else. Trust me I know how great it can be to have an offer running well, and I know the feelings I get when something bad happens to it. I still get pissed off and want to save it, but now I just accept it and move on to the next thing.
Most of the big money making offers are come and go, accept it, and rape it while you can.