You probably don’t stand a chance of building a site about mesothelioma, laser hair removal, or DUI lawyers and getting those very high paying ads to display on your site, much less get your site ranked in the search engines any longer. People and businesses who can afford to spend $50 to $100 per click to get traffic to their site are more than likely hiring someone who knows what they’re doing when it comes to Adwords, so it’s pretty certain they aren’t wasting their ads on your made for Adsense site.
To make long term consistent money from Adsense, you must base your site on keywords that pay relatively high, get lots of traffic, attract shoppers and are not based on a fad movements or lawsuit of the day clubs. When I say shoppers I mean people who are in a frame of mind to be looking at many different aspects of or products in the niche you are targeting.